Background Several jurisdictions, including Singapore, Australia, New Zealand and most recently Ireland, have a public interest or public good criterion for granting waivers of consent in biomedical research using secondary health data or tissue. However, the concept of the public interest is not well defined in this context, which creates difficulties for institutions, institutional review boards and regulators trying to implement the criterion. Main text This paper clarifies how the public interest criterion can be defensibly deployed. We first explain the (...) ethical basis for requiring waivers to only be granted to studies meeting the public interest criterion, then explore how further criteria may be set to determine the extent to which a given study can legitimately claim to be in the public interest. We propose an approach that does not attempt to measure magnitude of benefit directly, but rather takes into account metrics that are more straightforward to apply. To ensure consistent and justifiable interpretation, research institutions and IRBs should also incorporate procedural features such as transparency and public engagement in determining which studies satisfy the public interest requirement. Conclusion The requirement of public interest for consent waivers in secondary biomedical research should be guided by well-defined criteria for systematic evaluation. Such a criteria and its application need to be periodically subject to intra-committee and intra-institution review, reflection, deliberation and amendment. (shrink)

Solitons, i.e. solitary localized waves with particle-like behaviour, and multi-solitons occur virtually everywhere. There is a good reason for that in that there is a solid, albeit somewhat heuristic argument which says that for wave-like phenomena the 'soliton approximation' is the next one after the linear one. It is also not too difficult via some searching in the voluminous literature - many hundreds of papers on solitons each year - to write down a long list of equations which admit soliton (...) solutions and which model phenomena ranging over all the physical, biological, chemical and geological sciences as well as engineering. Yet, when lecturing on (mathematical) aspects of solitons I have found it not so easy to go beyond listing these equations. Largely because of lack of a book like this, which discusses where and how solitons arise, how they behave, whether or not they are stable and in what sense, which discusses approximate solitons and solitons in multidimensional spaces (which in a first simple natural formulation cannot exist), which discusses soliton (computer) experiments; all this for a wide range of phenomena especially in connection with solid state physics. There is a great deal of analytic material as well as there is especially a considerable collection of challenges for theoretical understanding. A great deal of the material covered in this book has not appeared in the monographic literature before. The phenomenology of solitons is very rich indeed. (shrink)

Methodology and ethics: these two terms have only recently begun to be linked organically in scientific thought, especially when the discussion is about man as the subject and object of knowledge. It is not as if this situation had not been anticipated in the history of thought. Suffice it to mention Kant's perspicuity: his analysis of "the conditions of the thinkability" of an object of knowledge is combined with ideas about man as an end in itself, as self-sufficient, and about (...) man's freedom, his ability to set goals in general. Crudely put, for Kant ethics is primary, it "anticipates" direct knowledge. (shrink)

Монография посвящена изучению рефлексии с позиций культурно-исторической и диалогической парадигм (М. М. Бахтин, Ю. М. Лотман, Л. С. Выготский и др.). В соответствии с принятой нами методологией был осуществлен анализ философско-методологических основ.

Collaborative research and development (R&D) activities between public universities and industry are of importance for the sustainable development of the innovation ecosystem. However, policymakers especially in developing countries show little knowledge on the issues. In this paper, we analyse the level of university–industry collaboration in Malaysia. We further examine the fundamental conditions that hinder university–industry collaboration despite the government’s initiatives to improve such linkages. We show that the low collaboration is a result of an R&D gap between the entities. While (...) the universities engage in basic and fundamental R&D, the private sectors involved in incremental innovation that requires less R&D investments. The different nature of the industries’ R&D requires closer cooperation between firms namely buyers, suppliers and technical service providers and not the universities. Among others, the lack of an intermediary role, absorptive capacity and collaborative initiative by the industry also contribute to the problem. The study suggests that the collaborative activities can benefit both if deliberate and effective efforts on reducing the R&D mismatch are made between the universities and industry. Likewise, proper institutional arrangements in coordinating these activities are required. This result seems to reflect the nature of many developing countries’ national innovation systems, and therefore, lessons from Malaysia may serve as a good case study. (shrink)

Philosophy in China has undergone a difficult course of development since 1949. During the first period of the existence of the Chinese People's Republic , there was a process of dissemination of the Marxist world-view among Chinese philosophers. A beginning was made in the treatment of current problems in the theory of the building of socialism. Studies in various areas of philosophical knowledge - dialectical and historical materialism, logic, ethics, esthetics, the history of philosophy - got under way. The discussions (...) that occurred in the mid-'50s reflected the fact that Chinese scholars in the realm of philosophy had attained a higher level of achievement. (shrink)

In the final analysis, sustainable agriculture must derive from applied ecology, especially the principle of the regulation of the abundance and distribution of species (and, secondarily, their activities) in space and time. Interspecific competition in natural ecosystems has its counterparts in agriculture, designed to divert greater amounts of energy, nutrients, and water into crops. Whereas natural ecosystems select for a diversity of species in communities, recent agriculture has minimized diversity in favour of vulnerable monocultures. Such systems show intrinsically less stability (...) and resilience to perturbations. Some kinds of crop rotation resemble ecological succession in that one crop prepares the land for successive crop production. Such rotations enhance soil organic processes such as decomposition and material cycling, build a nutrient capital to sustain later crop growth, and reduce the intensity of pest buildup. Species in natural communities occur at discrete points along the r-K continuum of reproductive maturity. Clearing forested land for agriculture, rotational burning practices, and replacing perennial grassland communities by cereal monocultures moves the agricultural community towards the r extreme. Plant breeders select for varieties which yield at an earlier age and lower plant biomass, effectively moving a variety towards the r type. Features of more natural landscapes, such as hedgerows, may act as physical and biological adjuncts to agricultural production. They should exist as networks in agricultural lands to be most effective. Soil is of major importance in agroecosystems, and maintaining, deliberately, its vitality and resilience to agricultural perturbations is the very basis of sustainable land use. (shrink)